In the present study, we provide evidence that CCL18 is primarily overexpressed in the cytoplasm and cell membrane of OSCC cells and that little colocalization is observed between CD68+ and CCL18+ staining in OSCC tissues, indicating that the increased CCL18 in oral cancer is predominantly produced by cancer epithelial cells, as opposed to TAMs. This evidence concerns the gene CD68 and lip and oral cavity carcinoma.