Based on the results shown in Figure 3D, and previous studies suggesting that Akt activation increases VEGF-A expression and is necessary and sufficient to regulate HIF-1α and VEGF expression in various human cancer cells [17–19], we postulated that the signal transduction of L-FABP-mediated VEGF-A expression was activated through the Akt pathway. The gene discussed is FABP1; the disease is cancer.