SOD1 and amyotrophic lateral sclerosis: Accumulation of detergent-insoluble, aggregated forms of mutant SOD1 have been found in motor neurons of ALS patients [25, 28], transgenic mouse models overexpressing mutant human SOD1 [26] as well as cells overexpressing human mutant SOD1s [27, 29, 30] and iPSCs-derived motor neurons [16, 31].