Although both hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause liver inflammation, they induce hepatocarcinogenesis through different mechanisms, and the upregulation of insulin-like growth factor-I receptor (IGF-IR) signaling is confined to HBV-related HCC (HBV-HCC) [13, 14]. The gene discussed is IGF1R; the disease is inflammatory response.