CDH1 and breast carcinoma: Interestingly, although both breast cancer cell lines are intrinsically deficient in E-cadherin (Figure 1C), indicating that they had lost an epithelial cell characteristic, the morphological change from an elongated and spindle-like fibroblastic shape to a cobblestone-like epithelial phenotype was observed when miR-30a was overexpressed (Figure 1D).