We examined the association of clinic-pathological parameters of patients and FSTL1 promoter hypermethylation (Table 1) and found no difference between FSTL1-hypermethylated and -nonmethylated cases in patient age, gender, cancer stage, histological subtype and lymph node metastasis, indicating that the promoter hypermethylation of FSTL1 might be an early event during NPC tumorigenesis. Here, FSTL1 is linked to nasopharyngeal carcinoma.