Overall, our present and previous studies provide several lines of evidence supporting a key role of GSH in hypoglycemia-induced cell death, including the up-regulation of Gpx3 and Gsto-1 expression at both mRNA and protein levels (see [3] and Fig 6), the alteration in GSH metabolism suggested by the GSAE analysis (Fig 2) and the demonstration of a causal role of GSH content modulation on retinal cell death [3]. This evidence concerns the gene GPX3 and Hypoglycemia.