The xeroderma pigmentosum (XP) genes, including complementation group C (XPC), D (XPD), F (XPF) and excision repair cross-complementation group1 (ERCC1), operate in NER pathway, and participate of recognition, demarcation and removal of DNA damage induced by CDDP and RT [7]. The gene discussed is ERCC4; the disease is xeroderma pigmentosum.