Fourthly, in a fatal acute infection model, parasite burdens in the heart depended on the ability of T. cruzi to replicate specifically in myeloid cells expressing Slamf1 (Calderón et al., 2012), which has a pro‐migratory function (van Driel et al., 2012; Wang et al., 2015). This evidence concerns the gene SLAMF1 and infection.