In univariate analysis, both membrane and cytoplasmic CDH1 expression, as well as nuclear HDAC3, were closely associated with overall survival (OS) of PC patients (P = 0.012, P < 0.001, and P < 0.001, respectively; Table 6), with Spearman correlation coefficients of 0.240, −0.435, and −0.530 (Supplementary Table S4), respectively. Here, HDAC3 is linked to pachyonychia congenita.