We obtained a nine-gene network of functional relationship predictions in the esophagus (Figure 7A) showing that Fbxw7, Stk40, and Pdcd4 were functionally related to several cancer-related genes, such as Pten, tumor suppressor of miR-21 [67, 68], oncogene Bcl2 [69], a Wnt signaling pathway transcription factor Tcf4 [70], the dead box protein family of RNA helicases Ddx6 [71, 72], fibroblast growth factor receptor 1 Fgfr1 [73–75], and Ppp3ca, a component of calcium/calcineurin signaling that includes apoptosis [76]. The gene discussed is PTEN; the disease is cancer.