The combinatorial effect of six up-regulated miRNAs (miR-691, miR-709, miR-31-5p, miR-5617-5p, miR-31-3p, and miR-185-3p) leads to the following important signaling pathways such as MAPK signaling, pathways in cancer, Ca+2 signaling, ubiquitin proteolysis, lysine degradation, endocytosis, glycosaminoglycan biosynthesis (chondroitin sulfate and keratin sulfate), Fc gamma-mediated phagocytosis, amphetamine addiction, bladder cancer, ECM-receptor interaction, steroid biosynthesis, dopaminergic synapse, and steroid hormone biosynthesis using pathways union mode. This evidence concerns the gene CA2 and cancer.