TNF and cancer: We found that the nine pathways related to transcriptional misregulation in cancer, biotin metabolism, MAPK signaling, lysine degradation, ubiquitin mediated proteolysis, cell cycle, gap junction, TGF-β signaling, and circadian rhythm, are affected due to sixteen down-regulated miRNAs between WT and WT+UVR mice; and seventeen down-regulated microRNAs between WT and TNFα KO mice.