Selective 9p24.1 amplification has been recently recognized as an important mechanism for increased PD-L1 expression in nodular sclerosing Hodgkins lymphoma and primary mediastinal large B-cell lymphoma [21] and has also been demonstrated in gastric carcinoma, colon carcinomas, triple-negative breast cancers and glioblastomas [22, 23]. The gene discussed is CD274; the disease is triple-negative breast carcinoma.