The aim of this pooled-analysis is to combine and analyze simultaneously all the studies reporting the ORR of pre-treated NSCLC patients receiving anti PD1/PD-L MoAbs, stratified according to the PD-L1 expression status (IHC, cut-off point 1%), in order to provide a more precise estimation of the predictive role of PD-L1 expression in NSCLC. This evidence concerns the gene CD274 and non-small cell lung carcinoma.