CD274 and neoplasm: Although different immunohistochemistry (IHC) cut-off points, ranging from 1% to 50%, have been used to define the PD-L1 positivity in tumor specimens, the results of the phase III CheckMate 057 study [24] have recently shown that PD-L1 (IHC, cut-off point 1%) significantly correlated with ORR, progression free survival (PFS) and overall survival (OS), in pre-treated NSCLC patients.