CD274 and non-small cell lung carcinoma: Indeed PD-L1 has shown to be predictive of Nivolumab activity at different cut offs of 1%, 5% and 10% [24], while in the more recent KEYNOTE-001 trial of pembrolizumab in advanced NSCLC, patients' survival significantly differed between patients with PD-L1 expression >50% in comparison with patients with a PD-L1 <50% [20].