CD274 and neoplasm: Indeed the CheckMate 017 study of Nivolumab in squamous NSCLC did not report any difference in terms of efficacy according to the tumor PD-L1 expression status [23], whereas the CheckMate 057 has recently shown that ORR nearly tripled and median OS nearly doubled with Nivolumab vs Docetaxel in pre-treated patients with PD-L1 positive non-squamous NSCLC [24].