Interestingly, some of them function as tumor suppressors (e.g. BCL2L11, MXD1, WWOX, BNIP3L, and DMTF1) or are candidate tumor suppressors having anti-proliferative properties and DNA repair abilities (e.g. LRRC2, RPA4, PPP6R1, SPEN, RAP1GAP and CISH) (see discussion section). The gene discussed is SPEN; the disease is neoplasm.