Overexpression of miR-489 inhibited cell growth and invasion and epithelial-to-mesenchymal transition (EMT) properties by targeting several genes including Shp2, Smad3, Akt3 and Suz12. In addition, loss of miR-489 expression confer tumor cells resistance to chemotherapeutic drugs [20]. This evidence concerns the gene PTPN11 and neoplasm.