The majority of genes in these pathways encode components of receptor signaling pathways and their ligands including ERBB2, JAK1, IL20RB, TLR3 and LIFR. Of note, the KEGG pathway Chronic myeloid leukemia, is enriched in both K-ras dependent and independent NSCLC cells, however, with the exception of NRAS, the specific genes regulated in this pathway are unique for each subtype. Here, KRAS is linked to non-small cell lung carcinoma.