Our studies describe a novel PKCδ->integrin αVβ3-> Extracellular signal-Regulated Kinase (ERK) pathway that is important for regulation of transformed growth specifically in K-ras dependent NSCLC cells, and suggest that perturbation of this pathway may be a novel therapeutic strategy for the subset of NSCLC patients with K-ras dependent tumors. The gene discussed is PRKCD; the disease is non-small cell lung carcinoma.