First, owing to a complex genetic trait that is determined by susceptibility genes in both the B-lymphocyte lineage (for example, Cdkn2a and Mtor) and the tumor microenvironment (for example, Mndal), C mice are highly susceptible to neoplasms of plasmablasts and plasma cells8—key constituents of KSHV-related B-cell disorders. This evidence concerns the gene CDKN2A and neoplasm.