Other pathways with a higher percentage of down-modulated genes at day 1 and up-modulated genes at day 2 and 3, or day 3 only, post infection in WT compared to Ifnar1-/- mice included activation of IRF by cytosolic pattern recognition receptors and the antigen presenting and dendritic cell maturation pathways respectively (Fig 4C). This evidence concerns the gene TRIM63 and infection.