IFNAR1 and infection: These data largely corroborated the data shown in Fig 4A–4C, with a dominance of the IFN signaling and antigen presentation pathways, where the transcripts in this case were more highly up-regulated in the blood of the Ifnar1-/- as compared to the WT mice at day 1 post infection, but down-regulated at days 2 or 3 post infection (Fig 5C).