The expression of transcripts classified as type I, both type I and type II as well as type II IFN responsive was elevated at day 1 (where bacterial loads are similar, Fig 3A), and diminished at day 3 (when the bacterial loads are reduced in the infected Ifnar1-/- mice, Fig 3A) in the Ifnar1-/- mice compared to the WT mice in the blood, spleen and liver following L. monocytogenes infection (Fig 8C), demonstrating how IFN responsive genes are differentially affected at different time points after infection. The gene discussed is IFNAR1; the disease is infection.