Statistical filtering (2-way ANOVA with Benjamini Hochberg multiple testing correction, P <0.05) revealed 588, 618 and 605 significantly differentially expressed IFN responsive transcripts in blood, spleen and liver during the course of infection (i.e. days 1, 2 and 3) which were differentially expressed in infected and uninfected Ifnar1-/- or WT mice (Fig 8A and 8B). The gene discussed is IFNAR1; the disease is infection.