Of the 42% of transcripts that were perturbed at day 1 post infection in the blood of Ifnar1-/- as compared to the WT mice, detailed IPA analysis showed increased expression of genes associated with antigen presentation, including Tap1, Nlrc5, Lmp2, and increased expression of Ifng, would suggest enhanced antigen presentation in the absence of type I IFN signaling. Here, NLRC5 is linked to infection.