Focusing on the expression of selected key IFN signaling genes (Irf1, Irf3, Irf7, Irf9, Stat1, Stat2; Fig 7E), we found firstly that Irf1 has similar baseline expression in WT and Ifnar1-/- mice, is induced by a similar degree upon infection and therefore its final expression is comparable between the mouse strains following infection. The gene discussed is IRF9; the disease is infection.