Amongst these genes dependent on IFNαβR signaling in the uninfected mice were IRGs including OAS family genes, IRF genes, and Stat1. We found that many of these same genes had similar FC induction following infection, however given the lower expression in the uninfected Ifnar1-/- compared to the WT their final expression remained lower in the infected Ifnar1-/- compared to the WT. This evidence concerns the gene SMOC1 and infection.