FOXP3 and Sepsis: Collectively, although previous studies and our results suggested that using anti-CD25 Abs to deplete T regs can improve immune status of sepsis [17, 19, 31], we need further explore specific antibodies or drugs to deplete Foxp3+ Treg cells, and need exactly determine the time of treatment and the level of T regs according to the condition of sepsis patients when using this therapeutic approach to treat sepsis in future.