IFNG and Sepsis: Upon IL-12 stimulation in vitro, the percentages of IFN-γ-producing T cells and NK cells significantly increased at 6 h post-LPS, then declined at 12 h post-LPS in either anti-CD25 mAb-treated sepsis mice or isotype control mAb-treated sepsis mice, and further decreased in isotype control mAb-treated sepsis mice at 24 h post-LPS, but did not further decrease in anti-CD25 mAb-treated sepsis mice at 24 h post-LPS (Figure 5C-5F).