ITGB4 and Familial prostate cancer: We examined its selectivity for inducing apoptosis in cells with differential expression of ITGB4: hepatic cells (L-02), human embryonic kidney cells (HEK293), and 4 kinds of tumor cells – prostatic cancer (PC3), lung carcinoma (A549), colorectal cancer (HCT116) and breast cancer (MCF-7) (Figure 1B).