CTHRC1 and melanoma: In addition, since we found that the expression of ITGB3 correlated with that of CTHRC1 in melanoma cells (Supplementary Table S5) and primary melanoma tissues (data not shown) (and we found no changes in the ITGB3 expression levels in CTHRC1-knockdown cells, data not shown), we examined whether CTHRC1 could be a downstream target of ITGB3 signaling.