Interestingly, in cultures of primary embryonic fibroblasts, endothelial cells, melanocytes, and melanoma cells from a primary tumor, CTHRC1 and FN1 were expressed similarly at a high level in fibroblasts, endothelial cells, and melanoma cells, whereas the ITGB3 expression was high in endothelial and melanoma cells but very low in fibroblasts, while NFATC2 seemed to be expressed only in the melanoma cells among the cell types tested (Figure 2C). This evidence concerns the gene ITGB3 and melanoma.