Since FN1 mRNA expression correlated with that of CTHRC1 in both melanoma cell cultures and primary melanoma tissues, we stained consecutive sections with a monoclonal antibody detecting cellular fibronectin (cFN; EDA+ FN1), finding that CTHRC1 and cFN co-localized in the fibroblasts or fibrillar structures surrounding melanoma cell nests and in blood vessels (Figure 3M–3O). This evidence concerns the gene FN1 and melanoma.