To determine which cell types are responsible for producing CTHRC1 in melanoma, we first used qRT-PCR to analyze the expression levels of CTHRC1 mRNA in primary human melanocytes, benign nevus cells, and melanoma cells isolated from primary tumors and lymph node metastases, as well as in primary human fibroblasts and endothelial cells. Here, CTHRC1 is linked to melanoma.