In addition, lnc-SOX2-1, also called SOX2-OT, can positively promote the transcription of SOX2 gene (one of the major regulators of pluripotency) and is dysregulated in esophageal squamous cell carcinoma, lung squamous cell carcinoma, and breast cancer [42]. This evidence concerns the gene SOX21 and esophageal squamous cell carcinoma.