PCa metastases have been associated with down-regulation of E-cadherin, Western blot analysis of E-cadherin protein expression demonstrated that MLL-FM-CP110Δ3′UTR tumor tissues with low metastatic potential had elevated levels (20%) of E-cadherin protein as compared to MLL-FM-CTRL tumor tissues with high metastatic potential (Figure 4e-4f). Here, CDH1 is linked to posterior cortical atrophy.