In the present study, we found that the 3-year OS, FFS, and D-FFS in the low tumor CTLA-4 expression group were significantly higher than those in the high tumor CTLA-4 expression group, although the low tumor CTLA-4 expression group had more early stage (stage I–II) patients than the high CTLA-4 expression group (18.3% vs. 10.2%, p = 0.047). Here, CTLA4 is linked to neoplasm.