Polymorphisms in various FCGR genes have been associated with clinical responses to certain monoclonal antibodies in cancer.92 It would be interesting to explore whether variants in FCGR1 might affect the vascular status or clinical response of patients to various human IgG1 antibodies, when they are administered at doses that would be expected to induce FcγRI-mediated signaling. This evidence concerns the gene FCGR1A and cancer.