Our data also suggest that it might be prudent to monitor potential effects of human IgG1 antibodies on the vasculature in other diseases, as we demonstrate is the case in IVIg-treated patients in a companion manuscript.88 Indeed, the minimal angioinhibitory dose of bevacizumab in mice, 15 mg/kg, is used in humans with many forms of cancer, suggesting that at this dose in people, the drug might have dual anti-angiogenic activity: via VEGFA inhibition and FcγRI-dependent pathways. This evidence concerns the gene VEGFA and cancer.