However, lung tissue had a significantly higher level of total doubly phosphorylated ERK1/2 than tumour when expressed either as total peak area (2630RU (SD 912) vs 1170RU (SD 355); p=0.006) or percentage peak contribution to total ERK (19.1% (SD 11.2; range 1.7–45.6%) vs 8.8% (SD 6.3; range 1.2–36.6%); p=0.002). Here, MAPK3 is linked to neoplasm.