Patients with autoimmune disease or autoimmune enteropathy, including those with immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, defects in interleukin-10 (IL-10) signaling pathways, gain-of-function STAT-3 disease, and CTLA-4 deficiency, have received curative transplants. The gene discussed is IL10; the disease is hyperinsulinemic hypoglycemia, familial, 4.