Platelet-activating factor antagonists such as lexipafant, antioxidants, corticosteroids, nitroglycerin, anti-interleukin-10 (anti-IL-10) antibodies, and anti-tumor necrosis factor-alpha (anti-TNF-α) antibodies have been shown to be of no value in the treatment of acute pancreatitis. The gene discussed is IL10; the disease is acute pancreatitis.