Given that both pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN protein were shown to be well tolerated in a number of early phase trials in HPV+ patients, and the absence of clinically apparent side effects when used in combination in the murine naïve and TC-1 tumor bearing animal studies described herein, this regimen is also likely to be well tolerated and immunogenic in HPV+ patients and therefore warrants further exploration in HPV+ patients. The gene discussed is PDXP; the disease is neoplasm.