CD8A and cervical squamous intraepithelial neoplasia: Since TA-CIN administration has been shown to generate HPV 16-specific humoral responses [18], we also verified whether boosting with TA-CIN following priming with pNGVL4a-Sig/E7(detox)/HSP70 DNA can lead to an enhanced HPV-16 E7-specific antibody responses similar to the enhanced E7-specific CD8+ T cell responses.