CD8A and neoplasm: Since a single boost with TA-CIN protein following two priming vaccinations with pNGVL4a-Sig/E7(detox)/HSP70 induced the most robust HPV16 E7-specific CD8+ T cell responses in both naïve and tumor-bearing mice, we therefore examined whether this was also associated with improved anti-tumor immunity against the HPV16 E6E7-expressing TC-1 transplantable tumor model.