PDXP and neoplasm: However, mice vaccinated twice with pNGVL4a-Sig/E7(detox)/HSP70 DNA followed by one TA-CIN protein vaccination boost generated a significantly more potent anti-tumor effect and survived significantly longer when compared to either untreated mice or mice vaccinated with pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine only (Fig. 6b, c).