Previous studies showed that gp100 encoded epitopes are recognized by tumor-infiltratinglymphocytes and circulating T-cells, associated with tumor regression in metastaticmelanoma patients after adoptive therapy (4, –, 7).Among these, the nonamer epitope gp100280–288 (YLEPGPVTA) wasoriginally shown to be recognized by HLA-A*0201+ tumor-infiltratinglymphocytes from melanoma patients (8) andsubsequently eluted from HLA-A*0201 molecules on melanoma cells (9). Here, PMEL is linked to melanoma.