EPG5 and Danon disease: The defects implicated in Danon disease (Nishino et al., 2000) and X-linked myopathy with excessive autophagy (MEAX) (Ramachandran et al., 2013), in particular impaired autolysosomal fusion and defective intralysosomal digestion, affect the same part of the autophagy pathway also affected in EPG5 deficiency.