HHIP and chronic obstructive pulmonary disease: The GYPA/HHIP and GPR126 regions have previously been reported as showing association with lung function and COPD or airflow limitation risk.3, 10, 14 The IFIT3 region signal (rs140549288 p.Val352Leu in IFIT3, OR: 1.92, MAF=0.7%, p=7.49×10−6) represents a novel rare variant signal of association with COPD.