We identified novel associations between COPD risk and low frequency or rare coding SNPs in two genes: MOCS3 (rs7269297, serine to alanine, MAF=1.3%, pdiscovery=3.08×10−6, PolyPhen prediction: benign) and IFIT3 (rs140549288, valine to leucine, MAF=0.7%, pmeta=8.56×10−6, PolyPhen prediction: benign). The gene discussed is MOCS3; the disease is chronic obstructive pulmonary disease.