MMP12 and chronic obstructive pulmonary disease: A further two loci were associated with COPD risk in the analysis unadjusted for pack-years: rs3827522 within PRICKLE1 (OR: 0.12, MAF=0.4%, p=1.03×10−7) and rs17368582 within MMP12 (OR: 0.712, MAF=12.2% p=5.01×10−6, table 2A and figure 2B); however, there was no evidence of replication of these associations with COPD risk in UK BiLEVE.