Two novel signals of association with COPD risk (p<10−5) were rs3813803 within SMPDL3B (OR: 1.37, MAF=29.2%, p=1.04×10−6) and low frequency SNP rs7269297 within MOCS3 (OR: 0.25, MAF=1.1%, p=3.08×10−6). The gene discussed is MOCS3; the disease is chronic obstructive pulmonary disease.