KDM5B belongs to the histone lysine demethylase family, with the ability to cause transcriptional silencing by specifically demethylating di- and tri- methylated lysine 4 of histone 3 of their target genes, and is overexpressed in several carcinomas, including gastric cancer, glioma and breast cancer [13, 14]. This evidence concerns the gene KDM5B and breast carcinoma.