Unravelling the molecular mechanism of KDM5B expression in TNBC cells remains a work in progress, however, taken together, our findings indicate that KDM5B is an epigenetic modulator of MALAT1 activity and its downstream effector genes, SNAI and vimentin, as well as plays a critical role in tumor invasion, survival, and niche colonization by the highly metastatic TNBC cells. Here, KDM5B is linked to neoplasm.