RB1 and breast neoplasm: Similar to KDM1A, KDM5B is involved in the silencing of breast tumor suppressors, including BRCA 1 [40], BRCA 2 [41], pRB [42], CAV1 [43], HOXA5 [44] and SFN [45], in addition to its active role in the signal transduction of hormone-regulated organs such as the ovaries, testes and breasts of gravid females, as well as, in transcriptional activation of androgen receptor (AR) [31, 33].