Observing a concomitant increase in MALAT 1 and KDM5B expression as breast cancer progresses, we investigated and validated the hypotheses that MALAT 1 interacts with KDM5B, and that the MALAT1 expression is positively regulated by that of KDM5B in the highly malignant and clinically challenging TNBC. This evidence concerns the gene KDM5B and breast carcinoma.