Of note is our finding that forced KDM5B expression in MCF-10A OE cells induced the acquisition of cancer stem cell-like phenotype in the KDM5B-deficient, non-tumorigenic MCF-10A cells, as evidenced by their markedly increased ability to form multiple large-sized mammospheres, analogous to those formed by the highly malignant TNBC cell, MDA-MB-231, which served as our positive control (Fig. 5e). The gene discussed is KDM5B; the disease is cancer.