SIRT1 and Sepsis: In the genes differentially expressed between SRS groups, there was evidence of enrichment for eQTL (χ2 p<0·0001), including for genes previously implicated in the pathogenesis of sepsis and its treatment, such as IL18RAP, CCR1, CCR3, and SIRT1 (appendix 1 pp 17–18 and appendix 2).