Mutations in PLN have been associated with dilated cardiomyopathy (DCM)6, 7, 8, hypertrophic cardiomyopathy (HCM)9 and recently arrhythmogenic right ventricular cardiomyopathy (ARVC) in North America and Europe10, but the role of PLN in Africans with cardiomyopathy is unknown11. Here, PLN is linked to hypertrophic cardiomyopathy.