Although the STOP-CKD study was unable to include patients with diabetes, the challenges faced by the study, and lessons learnt from it, have thus far been used to inform the ongoing Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) study,46 a large prospective, randomised, open blinded end point trial aiming to determine the effect of low-dose spironolactone on mortality and CV outcomes in patients with stage 3b CKD in primary care. This evidence concerns the gene NR3C2 and diabetes mellitus.