RUNX1 and breast carcinoma: To address the combinatorial regulation of AXIN1 by RUNX1 and oestrogens in clinical settings, we first calculated an ‘inhibitory index' for RUNX1 in each tumour in the breast cancer cohort of TCGA20 based on the expression levels of genes that RUNX1 inhibited in MCF7 cells (see ‘Methods' section).