Although genome-wide transcriptional regulation by RUNX1 is not generally dependent on oestrogens (Fig. 4c, Supplementary Fig. 3), such dependence at a few critical regulatory loci, such as AXIN1, may explain the specificity of RUNX1 recurrent mutations to ER+ breast cancer tumours18, 20. The gene discussed is AXIN1; the disease is breast carcinoma.