Muscle DG(18:0_20:4), DG(16:0_16:0), and DG(18:0_18:0) were increased in type 2 diabetes compared with nondiabetic individuals with similar obesity and lean athletes 7, and muscle Cer(d18:1/16:0) and Cer(d18:1/18:0) were increased in insulin‐resistant versus insulin‐sensitive women with obesity 8. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.