INS and obesity due to melanocortin 4 receptor deficiency: Subjects with body mass index (BMI) > 25 kg/m2 (n = 28) were stratified based on median glucose infusion rate during a hyperinsulinemic‐euglycemic clamp into insulin‐sensitive and insulin‐resistant groups (above and below median, obesity/insulin‐sensitive and obesity/insulin‐resistant, respectively).