Printy et al. [49] assessed atrophy profiles against genetic markers in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort, finding associations of cerebral atrophy with SNPs on APP but also ventricular enlargement with SNPs on SORCS1. Reitz et al. [53] also assessed the impact of genetic variation in SORCS1 and memory retention and found three SNPS were associated with memory retention. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.