However, the activation of autophagy in hTau40AT mice occurs only after NFT formation and onset of neuronal loss, obviously too late to rescue Tau induced toxicity and cognitive phenotype (Figs. 2, 8, 9 and 10), similar to old 3xTg-AD mice with NFTs showing no cognitive recovery after autophagy-activation [69]. This evidence concerns the gene MAPT and Alzheimer disease.