NOTCH1 and hepatocellular carcinoma: In order to decipher the mechanisms of the downregulation of CTNNB1 in HCC and CRC cells under the treatment of PS341, we focused on the negative transcriptional regulators of CTNNB1 such as VGLL4, FOXO3, SOX7, NOTCH1 and STAT326, 27, 28, 29, 30, 31.