In order to decipher the mechanisms of the downregulation of CTNNB1 in HCC and CRC cells under the treatment of PS341, we focused on the negative transcriptional regulators of CTNNB1 such as VGLL4, FOXO3, SOX7, NOTCH1 and STAT326, 27, 28, 29, 30, 31. Here, SOX7 is linked to hepatocellular carcinoma.