The western blot results indicated that the deletion of the binding sequence of FOXO3 in CTNNB1 promoter relieved the transcriptional inhibition of CTNNB1 mediated by FOXO3 and upregulated the expression of CTNNB1 in HCC and CRC Mut cells compared with that of HCC and CRC WT cells (Fig. 6g). The gene discussed is CTNNB1; the disease is colorectal carcinoma.