AXL and viral infectious disease: An early indication of this comes from a study of pseudotyped lentiviral particles which, when complexed with Tyro3/Axl/Mer (TAM) bridging molecules, Gas6 or Protein S, act as ‘super TAM agonists' that disable host immune responses and facilitate virus spread.73 In this study, the authors demonstrate that enhancement of viral infection is associated with TAM-mediated inhibition of type I IFN signaling.