HAVCR2 and cancer: One active area of research is investigating the role of TIM-3 in T-cell exhaustion, which is a defective T-cell response found in many chronic infections and in cancer.60 In a recent study investigating TIM-3 signaling pathways, Rangachari et al.61 found that HLA-B-associated transcript (Bat3), a chaperone protein known to bind to the intracellular tail of TIM-3, associates with the active domain of Lck.