Daily subcutaneous administration of ENPP1‐Fc, a soluble, recombinant protein with the extracellular domain of ENPP1 fused to the fragment crystallisable (Fc) region of human immunoglobulin G1 (IgG1), was effective against GACI in a mouse model 145. The gene discussed is ENPP1; the disease is arterial calcification, generalized, of infancy, 1.