Increased expression of osteochondrogenic markers including SRY (sex determining region Y)‐box 9 (SOX9) and Msh Homeobox 2 (MSX2) has been observed in dense proteoglycan‐rich lesion onlays with the HF/HC diet 61 as have complicated atherosclerotic lesions with ectopic calcification 77. The gene discussed is MSX2; the disease is hydrops fetalis.