Among these patients, 43% (92/216) of patients developed grade 3 and 4 thrombocytopenia; 25% (52/211) developed grade 3 and 4 neutropenia; 20% (42/207) developed grade 3 and 4 hypertension; 17% (37/217) developed grade 3 and 4 leucopenia; 8.4% (18/215) has increased AST/ALT level and 6.5% (14/214) developed grade 3 hand-foot syndrome. The gene discussed is GPT; the disease is hypertensive disorder.