WEE1 and cancer: It is known that activation of tyrosine kinase increases tumor cell growth and proliferation, induces anti-apoptotic effects, as well as promotes angiogenesis and metastasis.[1] Additionally, activation of growth factors and protein kinase by somatic mutation in cancer cells is a common phenomenon in tumorigenesis.[2–4] Taken all these factors into consideration, inhibition of tyrosine kinase has become one of the major targets to develop cancer therapy.