GPT and Hand-foot syndrome: The association remained suggestively significant with severe thrombocytopenia (P = 5.18x10-3, OR = 2.26, 95% CI = 1.28–4.00), fever (P = 1.78x10-2, OR = 2.83, 95% CI = 1.20–6.70) and increased levels of AST and ALT (P = 3.71x10-2, OR = 3.40, 95% CI = 1.08–10.72) after adjusting the significant clinical variables (gender for leucopenia, ECOG performance status for hand-foot syndrome and age for proteinuria as well as thrombocytopenia) as confounding factors that might affect the association (Table 3).