However, others have reported CR1 mRNA expression in phagocytic Kolmer cells of the choroid plexus (by in situ hybridization) [55], anti-CR1 reactivity on brain Kolmer and ependymal cells though only during bacterial meningitis [56], and anti-CR1 staining of microglia and neurons [57,58], none of which we were able to replicate in our normal, MCI or AD brains or in human brain derived microglial cultures. This evidence concerns the gene CR1 and Alzheimer disease.