This suggests that decreased TRESK channel activity might exacerbate migraine pain and that activators of TRESK channels might provide a useful therapeutic approach in pain, particularly given their rather restricted expression in certain central neurons, spinal cord and nociceptive sensory neurons (Kang and Kim, 2006; Dobler et al., 2007; Lafrenière et al., 2010; Marsh et al., 2012). The gene discussed is KCNK18; the disease is migraine disorder.