INS and Insulin resistance: High-fat diet induced an increase in the fasting serum levels of glucose and insulin, accompanied by an increase of HOMA-IR and decrease of HOMA-IS index, while the mice in HFDJ group revealed a significant decrease in the fasting serum glucose and insulin levels and HOMA-IR index but a distinct increase of HOMA-IS index compared to mice in HFD group (Fig 3), suggesting that WPJ significantly improved high-fat diet-induced hyperglycemia and insulin resistance in mice.