TP53 and malignant colon neoplasm: Interestingly, it has been formerly reported that most mouse colon tumors induced by the AOM-DSS treatment do not contain p53 mutations or misregulation (Nambiar et al, 2004; Takahashi and Wakabayashi, 2004), and this may provide an explanation of why Sestrin2 expression is sustained in this specific mouse model of colon cancer.