SESN2 and colonic neoplasm: Consistent with this observation, phosphorylation of eukaryotic translation initiation factor 4E-binding protein (4E-BP), an additional mTORC1 target, was also prominently increased in Sesn2-/- colon cancer tissues, when compared to adjacent normal colon tissues as well as to WT colon cancer tissues (Figure 6F and Figure 6—figure supplement 2B).