In contrast, other major cell type markers, such as Villin (VIL1, enterocytes), DLL1 (progenitor cells), F4/80 (EMR1, macrophages), Gr-1 (LY6G5B, leukocytes), or β-catenin (CTNNB, colon epithelia), did not show such strong suppression (Figure 3—figure supplement 1A–E), while the stem cell marker LGR5 was rather upregulated in tumor samples (Figure 3—figure supplement 1A–E). The gene discussed is LY6G5B; the disease is neoplasm.