SESN2 and colonic neoplasm: Surprisingly, in virtually all of the colon cancer transcriptome studies available within the database, which were conducted in diverse platforms using different patient tissues, human Sestrin2 (SESN2) mRNA expression was strongly downregulated in colon adenocarcinoma tissues when compared to normal colon controls (Figure 3A–G) (Gaspar et al, 2008; Graudens et al, 2006; Hong et al, 2010; Kaiser et al, 2007; Cancer Genome Atlas Network, 2012; Skrzypczak et al, 2010).