The increased susceptibility of Sesn2-/-/Sesn3-/- mice to DSS-induced injury (Figure 1—figure supplement 1A–C) was recapitulated in Sesn2-/- mice; although both WT and Sesn2-/- mice develop severe colitis with one week of DSS treatment (Figure 1D and Figure 1—figure supplement 2), WT mice successfully recovered from injury after one additional week of regular water treatment, while Sesn2-/- mice did not (Figure 1D–F). This evidence concerns the gene SESN3 and colitis.