In contrast, other major cell type markers, such as Villin (VIL1, enterocytes), DLL1 (progenitor cells), F4/80 (EMR1, macrophages), Gr-1 (LY6G5B, leukocytes), or β-catenin (CTNNB, colon epithelia), did not show such strong suppression (Figure 3—figure supplement 1A–E), while the stem cell marker LGR5 was rather upregulated in tumor samples (Figure 3—figure supplement 1A–E). This evidence concerns the gene LGR5 and neoplasm.