Quantification of PCNA-, γ-H2AX- and TUNEL-positive cells showed that tumor cell proliferation (Figure 5L) is significantly increased in tumors isolated from Sesn2-/- mice, while DNA damage (Figure 5M) and apoptosis (Figure 5N) were not significantly altered by the loss of Sestrin2. The gene discussed is SESN2; the disease is neoplasm.