APP and Alzheimer disease: On the basis of the relevance between NRG1 and AD, we found that soluble NRG1 can prevent Aβ1-42-induced impairment of LTP in a previous study.17 In addition, NRG1 has been shown to alleviate the cytotoxic effects of Aβ1-42, Swedish APP and C-terminal fragments of APP,18, 19 proposing that NRG1 may have protective effects in AD.